Anupama Ghosh

Anupama Ghosh
Assistant Professor

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Research interests:

  1. Functional studies on secreted effector proteins from different phytopathogenic fungi
  2. defense mechanisms of host plants against pathogen invasion involving apoplastic proteins

Contact:

Address: Division of Plant Biology
Centenary Campus
Bose Institute
P-1/12 C.I.T. Scheme VII-M
Kolkata - 700054, India
E-Mail: ghosh.anupama[at]jcbose.ac.in
Phone: +91-33-25693348

Research:

·         Survival strategies of corn smut fungus Ustilago maydis during host colonization

Ustilago maydis is a biotrophic fungus that infects Zea mays. During host colonization the fungus is exposed to a number of plant defense responses like for instance elevated levels of reactive oxygen species (ROS) in the vicinity of the invasion site. Depending upon the compatibility of the pathogen and the host strain this ROS stimuli can either initiate a cell death response in the pathogen or could be overcome by the defense responses of the pathogen itself. In this project we are engaged in dissecting these survival and death pathways of Ustilago maydis during a compatible and incompatible interaction with the host plant Zea mays.

 

·         Functional characterization of U. maydis effector proteins

Effector proteins are key factors defining the virulence of a phytopathogenic fungus like Ustilago maydis. In this project we are engaged in investigating the functions of different groups of secreted effector proteins from Ustilago maydis in the context of their role in manipulating host defense responses.

 

·         Functional proteomics of rice apoplastic fluid

This project is aimed to study the apoplastic fluid proteome of rice under conditions of pathogen invasion. Through this study we are investigating on one hand the in-planta secretome of different pathogens infecting rice and on the other hand rice secreted proteins that play crucial roles in defense against pathogen invasion.  

 

Publications:

1.     Mukherjee D, Saran N, Gupta S, Datta R, Ghosh A*. Clearance of stress induced intracellular protein aggregates: an unconventional role for Ustilago maydis metacaspase. (under review)

2.     Ghosh P, Roy A, Hess D, Ghosh A,  Das S. Deciphering the Mode of Action of a Modified Allium sativum Leaf Agglutinin (mASAL), a Potent antifungal Protein on Rhizoctonia solani. BMC Microbiology 2015; Oct 26;15:237.

3.     Ghosh A*, Raha S. Molecular and functional characterization of a stress responsive cysteine protease, EhCP6 from Entamoeba histolytica. Protein Expression and Purification 2015  May;109:55-61. doi: 10.1016/j.pep.2015.02.005.

4.     Ghosh A*. Small heat shock proteins (HSP12, HSP20 and HSP30) play a role in Ustilago maydis pathogenesis. FEMS Microbiology Letters 2014 Sep 22; doi: 10.1111/1574-6968.12605

5.     Djamei A£, Schipper K£, Rabe F, Ghosh A, Vincon V, Kahnt J, Osorio S, Tohge T, Fernie AR, Feussner I, Feussner K, Meinicke P, Stierhof YD, Schwarz H, Macek B, Mann M, Kahmann R. Metabolic priming by a secreted fungal effector. £Contributed equally Nature 2011 Oct 5; 478(7369): 395-8. doi: 10.1038/nature10454.

6.     Ghosh AS, Ray D, Dutta S, Raha S. EhMAPK, the mitogen-activated protein kinase from Entamoeba histolytica is associated with cell survival. PLoS One 2010 Oct 8; 5(10): e13291. doi: 10.1371/journal.pone.0013291.

7.     Ghosh AS, Dutta S, Raha S. Hydrogen peroxide-induced apoptosis-like cell death in Entamoeba histolytica. Parasitology International 2010 Jun; 59(2): 166-72. doi: 10.1016/j.parint.2010.01.001. Epub 2010 Jan 15.

8.     Dutta S, Sardar A, Ray D, Raha S. Molecular and functional characterization of EhPAK3 a p21 activated kinase from Entamoeba histolytica.Gene 2007 Nov 1;402(1-2):57-67.

9.     Ray D, Ghosh A, Banerjee Mustafi S, Raha S. Plant stress response: HSP70 in the spotlight. chapter in book entitled “Heat shock proteins and plants” 2016 , Springer publishers.

 

*Author for correspondence

 

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Recognition:

    Teaching:

    " Plant Molecular Biology Course " in the Integrated M.Sc. PhD Programme of Bose Institute. 

    Topics covered:

    1. Transport of micro and macro molecules

    2. Plant stress signalling during pathogen (bacterial and fungal phytopathogens) invasion 

     

                             

    Present:

    Image Name Designation Department Campus Contact number Email
    profile image Dibya Mukherjee SRF Division of Plant Biology Centenary 25693348 mukherjee.dibya90@gmail.com
    profile image Rahul Datta SRF(I) Division of Plant Biology Centenary 25693348 rahuldatta638@gmail.com
    profile image Subhasish Mukherjee JRF Division of Plant Biology Centenary 25693348 s.mukherjee
    profile image Udita Acharya JRF Division of Plant Biology Centenary 25693348 uditaacharya11

    Former:





















    Rahul Datta, JRF (Email: rahuldatta638@gmail.com) 

    Dibya Mukherjee, JRF (Email: mukherjee.dibya90@gmail.com)

    Udita Acharya, JRF (Email: uacharya93@gmail.com)

    Subhasish Mukherjee, JRF (Email: mukherjeesubhasish30@gmail.com)

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