Joyoti Basu
Senior Professor,  Chemistry
PhD(Biochemistry):University of Calcutta (1988)

Current area of research   :  Cellular and molecular biology
                           of mycobacteria; innate immunity

Specific  interests:

a.       Understanding proteins/enzymes of the cell wall biosynthesis and cell division machinery of mycobacteria at the structural and functional level as an approach towards developing agents for antimycobacterial chemotherapy.

b.       Understanding the stress response of mycobacteria at the system level.

c.       Dissecting mechanisms of mycobacterial pathogenesis.

d.       Global profiling approaches to understand how pathogenic mycobacteria regulate the innate immune response at the system level.

Selected publications 

  1.  Gupta, S., Banerjee, S.K., Chatterjee, A., Sharma, A.K., Kundu, M., and  Basu, J. (2015) The essential protein SepF of mycobacteria interacts with FtsZ and MurG to regulate cell growth and division. Microbiology, doi: 10.1099/mic.0.000108.  PMID: 25971440

  2. Sharma, A.K., Chatterjee, A., Gupta, S., Banerjee, R., Mandal, S., Mukhopadhyay, J., Basu, J., and  Kundu, M. (2015) MtrA, an essential response regulator of the MtrAB two component system regulates the transcription of resuscitation promoting factor B (RpfB) of Mycobacterium tuberculosis. Microbiology,  doi:10.1099/mic.0.000087. PMID: 25833257

  3.  Kumar, M., Sahu, S.K., Kumar, R., Subuddhi, A., Maji, R.K., Jana, K., Gupta, P., Raffetseder, J., Lerm, M., Ghosh, Z., van Loo, G., Beyaert, G., Gupta, U.D., Kundu, M., and Basu, J. (2015) MicroRNA let-7- modulates  the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-kappa B pathway. Cell Host and Microbe, 17, 1-12.

  4.  Basu, J., Shin, D.-M., and Jo, E.K. (2012) Mycobacterial signaling through toll-like receptors. Front Cell Infect Microbiol.  2, 145.

  5. Kumar, R., Halder, P., Sahu, S.K., Kumar, M., Kumari, M., Jana, K., Ghosh, Z., Sharma, P., Kundu, M. and Basu, J (2012) Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis. Cellular Microbiology, 141, 1620-1631.

  6. Natarajan, K., Kundu, M., Sharma, P., and Basu J. (2011) Innate immune responses to M. tuberculosis infection. Tuberculosis (Edinb). 91, 427-431

  7. Dasgupta, A., Sureka, K., Mitra, D.,  Saha, B., Sanyal, S.,  Das,  A.K., Chakrabarti, P., Jackson, M., Gicquel, B., Kundu, M., and Basu, J.  (2010) An oligopeptide tansporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages. PLoS ONE  5 :  e12225



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