Joyoti Basu
Senior Professor,  Chemistry
PhD(Biochemistry):University of Calcutta (1988)


Current area of research   :  Cellular and molecular biology
                           of mycobacteria; innate immunity

Specific  interests:

a.       Understanding proteins/enzymes of the cell wall biosynthesis and cell division machinery of mycobacteria at the structural and functional level as an approach towards developing agents for antimycobacterial chemotherapy.

b.       Understanding the stress response of mycobacteria at the system level.

c.       Dissecting mechanisms of mycobacterial pathogenesis.

d.       Global profiling approaches to understand how pathogenic mycobacteria regulate the innate immune response at the system level.

Further interests at : http://www.boseinst.ernet.in/sysbio/

Selected publications 

1. Dasgupta, A., Sureka, K., Mitra, D.,  Saha, B., Sanyal, S.,  Das,  A.K., Chakrabarti, P., Jackson, M., Gicquel, B., Kundu, M., and Basu, J.  (2010) An oligopeptide tansporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages. PLoS ONE  5 :  e12225 

2.Kundu, M., Pathak, S.K., Kumawat, K., Basu, S., Chatterjee, G., Pathak, S.,  Noguchi, T.,  Takeda, K.,  Ichijo, H., Thien,  C.B.F.,. Langdon, W.Y. and  and Basu, J. A tumor necrosis factor- and c-Cbl-dependent FLIPS degradation pathway and its role in Mycobacterium tuberculosis-induced macrophage apoptosis   (2009) Nature Immunol. 10, 918-925 

3. Barik, S., Sureka, K., Basu, J., and Kundu, M. RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis. (2010) Mol. Microbiol. doi.: 10.1111/j/1365-2958.2009.07008x 

4. Mukherjee, P., Sureka, K., Datta, P., Hossain, T., Barik, S., Das, K.P., Kundu, M., and Basu, J. Novel role of Wag31 in protection of mycobacteria under oxidative stress. (2009) Mol. Microbiol. 73, 113-119 

5. Sureka, K., Ghosh, B., Dasgupta, A., Basu, J., Kundu, M. and Bose, I. Positive feedback and noise activate the stringent response regulator Rel in mycobacteria. (2008) PLoS One, vol. 3, e1771. 

6. Pathak,  S.K., Basu, S., Basu,  K.K., Banerjee, A., Pathak,  S., Bhattacharyya, A., Kaisho, T., Kundu,  M., and Basu,  J. Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. (2007) Nat Immunol. 8, 610-618  

7. Basu, S.,  Pathak, S.,  Pathak, S.K.,  Bhattacharyya, A.,  Banerjee, A.,  Kundu, M. and  Basu, J.  Mycobacterium avium-induced matrix metalloproteinase-9 expression occurs in a cyclooxygenase-2-dependent manner and involves phosphorylation- and acetylation-dependent chromatin modification  (2007) Cellular Microbiology  9, 2804-2816 

8. Basu, S.,  Pathak,  S.K., Banerjee, A., Pathak, S.,  Bhattacharyya, A.,  Yang, Z., Talarico, S., Kundu, M. and Basu, J. Execution of macrophage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-α  (2007) J. Biol. Chem.  282, 1039–1050 

9. Sureka, K., Dey, S., Datta, P., Singh, A.K., Dasgupta, A., Rodrigue, S., Basu, J., Kundu, M. Polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria. (2007) Mol. Microbiol. 65, 261-276 

10. Datta, P., Dasgupta, A., Singh, A.K., Mukherjee, P., Kundu, M., and Basu, J.  Interaction between FtsW and penicillin-binding protein (PBP)3 directs PBP3 to mid-cell, controls cell septation and mediates the formation of a trimeric complex involving  FtsZ, FtsW and PBP3 in mycobacteria (2006) Mol. Microbiol.  62, 1655–1673 

11. Pathak,  S.K., Basu, S., Bhattacharyya, A., Pathak, S., Kundu, M. and  Basu J. Mycobacterium tuberculosis lipoarabinomannan-mediated irak-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages. (2005) J. Biol. Chem. 280, 42794-42800 

12. Datta, P., Dasgupta, A., Bhakta, S.,  and Basu, J. (2002) Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. J. Biol. Chem. 277, 24983-24987.

Full list of publications

 

Contact:

Phone: 91 33 23031153 (office)
E-mail: joyotibasu@gmail.com; joyoti@vsnl.com; joyoti@bosemain.boseinst.ac.in