Manikuntala Kundu
Senior Professor, Chemistry

PhD(Biochemistry): University of Calcutta(1988)


Research interests

        i.            Dissecting host-pathogen interactions with reference to Helicobacter pylori and pathogenic mycobacteria.

      ii.            Understanding the stress response in mycobacteria with special reference to  extracytoplasmic function sigma factors and two-component systems


Selected publications:

  1. Gupta, S., Banerjee, S.K., Chatterjee, A., Sharma, A.K., Kundu, M., and  Basu, J. (2015) The essential protein SepF of mycobacteria interacts with FtsZ and MurG to regulate cell growth and division. Microbiology, doi: 10.1099/mic.0.000108.  PMID: 25971440

  2.  Sharma, A.K., Chatterjee, A., Gupta, S., Banerjee, R., Mandal, S., Mukhopadhyay, J., Basu, J., and  Kundu, M. (2015) MtrA, an essential response regulator of the MtrAB two component system regulates the transcription of resuscitation promoting factor B (RpfB) of Mycobacterium tuberculosis. Microbiology,  doi:10.1099/mic.0.000087. PMID: 25833257

  3.  Halder, P., Datta, C., Kumar, R., Sharma, A.K., Basu, J., and Kundu, M. (2015) The secreted antigen, HP0175, of Helicobacter pylori links the unfolded protein response (UPR) to autophagy in gastric epithelial cells.  Cellular  Microbioliogy  17, 714-729

  4.  Kumar, M., Sahu, S.K., Kumar, R., Subuddhi, A., Maji, R.K., Jana, K., Gupta, P., Raffetseder, J., Lerm, M., Ghosh, Z., van Loo, G., Beyaert, G., Gupta, U.D., Kundu, M., and Basu, J. (2015) MicroRNA let-7- modulates  the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-kappa B pathway. Cell Host and Microbe, 17, 1-12.

  5.  Amedei, A., Munari, F., Della Bella, C., Niccolai, E., Benagiano, M., Bencini, L., Cianchi, F., Farsi, M., Emmi, G., Zanotti, G., de Bernard, M., Kundu, M., and D'Elios, M. M. Helicobacter pylori secreted peptidyl prolyl cis,trans-isomerase drives Th17 inflammation in gastric adenocarcinoma. (2014) Internal and Emergency Medicine 9, 303-309

  6.  Sanyal, S., Banerjee, S.K., Banerjee, R., Mukhopadhyay, J., Kundu M.(2013)Polyphosphate kinase 1, a central node in the stress response network of Mycobacterium tuberculosis, connects the two-component systems MprAB and SenX3-RegX3 and the extracytoplasmic function sigma factor, sigma E.  Microbiology 159, 2074-2086

  7.  Amedei, A., Munari, F., Della Bella, C., Niccolai, E., Benagiano, M., Bencini, L., Cianchi, F., Silvestri, E., D’Elios, S., Farsi, M., Prisco, D., Zanotti, G., de Bernard, M., Kundu, M., and D’Elios, M. M. Helicobacter pylori HP0175 promotes the production of IL-23, IL-6, IL-1β and TGF-β. (2013) Eur. J. Immunol. 11, 261-268.

  8.  Kumar, R., Halder, P., Sahu, S. K., Kumar, M., Kumari, M., Jana, K., Ghosh, Z., Sharma, P., Kundu, M., and Basu, J. Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis. (2012) Cellular  Microbiology 14, 1620-1631

  9.  Natarajan, K., Kundu, M., Sharma, P., and Basu J. Innate immune responses to M. tuberculosis infection. (2011)  Tuberculosis (Edinb). 91, 427-431

  10.  Dasgupta, A., Sureka, K., Mitra, D.,  Saha, B., Sanyal, S.,  Das,  A. K., Chakrabarti, P., Jackson, M., Gicquel, B., Kundu, M., and Basu, J.  (2010) An oligopeptide tansporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages. PLoS ONE  5 :  e12225


Phone: 033 23031153 (office)
Fax: 033 23506790