Manikuntala Kundu
Senior Professor, Chemistry
PhD(Biochemistry): University of Calcutta(1988)

Publications

Dasgupta, A., Sureka, K., Mitra, D.,  Saha, B., Sanyal, S.,  Das,  A.K., Chakrabarti, P., Jackson, M., Gicquel, B., Kundu, M., and Basu, J.  (2010) An oligopeptide tansporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages. PLoS ONE  5 :  e12225 

Sureka K, Hossain T, Mukherjee P, Chatterjee P, Datta P, Kundu M, Basu J. (2010) Novel role of phosphorylation-dependent interaction between FtsZ and FipA in mycobacterial cell division.PLoS One. 5: e8590. 

Barik, S., Sureka, K., Basu, J., and Kundu, M. RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis. (2009) Mol. Microbiol. doi.: 10.1111/j/1365-2958.2009.07008x

Kundu, M., Pathak, S.K., Kumawat, K., Basu, S., Chatterjee, G., Pathak, S.,  Noguchi, T.,  Takeda, K.,  Ichijo, H., Thien,  C.B.F.,. Langdon, W.Y. and  and Basu, J. A tumor necrosis factor- and c-Cbl-dependent FLIP_S degradation pathway and its role in Mycobacterium tuberculosis-induced macrophage apoptosis   (2009) Nature Immunol. 10, 918-925 

Basu, S., Pathak, S.K., Chatterjee, G., Pathak, S., Basu, J., Kundu, M. Helicobacter pylori protein HP0175 transactivates EGFR through TLR4 in gastric epithelial cells. (2008) J. Biol. Chem. 283, 32369-32376

Pazhani, G.P., Niyogi, S.K., Singh, A.K., Sen, B.,  Taneja, N., Kundu, M.,  Yamasaki, S., Ramamurthy, T. Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India.  (2008) J.  Med. Microbiol. 57, 856–863 

Sureka, K., Ghosh, B., Dasgupta, A., Basu, J., Kundu, M. and Bose, I. Positive feedback and noise activate the stringent response regulator Rel in mycobacteria. (2008) PLoS One, 3: e1771 

Sureka, K., Dey, S., Datta, P., Singh, A.K., Dasgupta, A., Rodrigue, S., Basu, J., Kundu, M. Polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria. (2007) Mol. Microbiol. 65, 261-276 

Pathak, S.K.,  Bhattacharyya, A., Basu, S., Banerjee, A., Basu, J., and Kundu, M.  TLR4-dependent NF-kappa B activation and mitogen- and stress-activated proteins kinase 1-triggered phosphorylation events are central to Helicobacter pylori peptidyl prolyl cis-, trans- isomerase (HP0175)-mediated induction of IL-6 release from macrophages. (2006) J. Immunol. 177, 7950-7958 

Singh, A., Halder, R., Mandal, D., and Kundu, M. Analysis of the topology of Vibrio cholerae NorM and identification of amino acid residues involved in norfloxacin resistance. (2006) Antimicrob. Agents Chemother. 50, 3717-3723.  

Pathak,  S.K., Basu, S., Basu,  K.K., Banerjee, A., Pathak,  S., Bhattacharyya, A., Kaisho, T., Kundu,  M., and Basu,  J. Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. (2007) Nat Immunol. 8, 610-618  

Basu, S.,  Pathak, S.,  Pathak, S.K.,  Bhattacharyya, A.,  Banerjee, A.,  Kundu, M. and  Basu, J.  Mycobacterium avium-induced matrix metalloproteinase-9 expression occurs in a cyclooxygenase-2-dependent manner and involves phosphorylation- and acetylation-dependent chromatin modification  (2007) Cellular Microbiology  9, 2804-2816 

Basu, S.,  Pathak,  S.K., Banerjee, A., Pathak, S.,  Bhattacharyya, A.,  Yang, Z., Talarico, S., Kundu, M. and Basu, J. Execution of macrophage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-α  (2007) J. Biol. Chem.  282, 1039–1050 

Datta, P., Dasgupta, A., Singh, A.K., Mukherjee, P., Kundu, M., and Basu, J.  Interaction between FtsW and penicillin-binding protein (PBP)3 directs PBP3 to mid-cell, controls cell septation and mediates the formation of a trimeric complex involving  FtsZ, FtsW and PBP3 in mycobacteria (2006) Mol. Microbiol.  62, 1655–1673 

Mukherjee, P., Dutta, M., Datta, P., Dasgupta, A., Pradhan, R., Pradhan, M., Kundu, M., and Basu, J., and Chakrabarti, P. The RD1-encoded antigen Rv3872 of Mycobacterium tuberculosis as a potential candidate for serodiagnosis of tuberculosis. (2007) Clin. Microbiol.  Infect. 13, 146-152 

Kundu M, and Basu J.IL-32: An Emerging Player in the Immune Response Network against Tuberculosis? (2006) PLoS Med. 18, 3(8) 

Dasgupta, A., Datta, P., Kundu, M., and Basu, J. The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division. (2006) Microbiology 152, 493-504 

Basak, C.,  Pathak, S.K.,  Bhattacharyya, A.,  Pathak, S.,  Basu, J.  and Kundu, M.  The secreted peptidyl prolyl cis,trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a Toll-like receptor 4 and apoptosis signal-regulating kinase 1(ASK1)-dependent manner. (2005) J. Immunol., 174, 5672-5680 

Basak, C., Pathak, S., Bhattacharyya, A., Mandal, D.,  Pathak, S.,  and Kundu, M.  NF-kB- and C/EBPb-driven interleukin-1b gene expression and PAK1-mediated caspase 1 activation play essential roles in interleukin-1b release from Helicobacter  pylori lipopolysaccharide (LPS)-stimulated macrophages.  (2005) J. Biol. Chem. 280, 4279-4288  

Mandal, D., Mazumder, A., Das, P., Kundu, M. and Basu J.  FAS-, caspase 8-and caspase 3-dependent signaling regulate the activity of the aminophospholipid translocase and phosphatidylserine externalization in human erythrocytes. (2005) J. Biol. Chem. 280, 39460-39467 

Pathak,  S.K., Basu, S., Bhattacharyya, A., Pathak, S., Kundu, M. and  Basu J. Mycobacterium tuberculosis lipoarabinomannan-mediated irak-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages. (2005) J. Biol. Chem. 280, 42794-42800

Pathak, S.K., Bhattacharyya, A., Pathak, S., Basak, C., Mandal, D., Kundu, M. and Basu, J. (2004) Toll-like receptor 2 and mitogen and stress-activated kinase 1 are effectors of Mycobacterium avium- induced cyclooxygenase-2 expression in macrophages. J. Biol. Chem. 279, 55127-55136 

Mills, J.A.,  Motichka, K.,  Jucker, M.,  Wu, H.P.,  Uhlik, B.C.,  Stern, R.J.,  Scherman, M.S.,  Vissa, V.D.,  Pan, F.,  Kundu, M.,  Ma, Y.F.  and Michael McNeil (2004) Inactivation of the Mycobacterial Rhamnosyltransferase, Which Is Needed for the Formation of the Arabinogalactan-Peptidoglycan Linker, Leads to Irreversible Loss of Viability. J. Biol. Chem. 279, 43540-43546 

Bhattacharyya, A., Pathak, S., Basak, C., Law, S., Kundu, M. and Basu, J. (2003) Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated kinase signaling and caspase 8 activation. J. Biol. Chem. 278, 26517-26525 

Bhattacharyya, A., Pathak, S., Datta, S., Chattopadhyay, S., Basu, J. and  Kundu, M. (2002)  Mitogen-activated protein  kinases and NF-kB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages. Biochem. J. 368, 121-129 

Bhattacharyya, A., Pathak, S., Kundu, M. and Basu, J. (2002) Mitogen-activated protein kinases regulate  Mycobacterium avium-induced tumor necrosis factor-a release from macrophages. FEMS Immunology and Medical Microbiology. 34, 73-80.

Baranwal, S., Dey, K., Ramamurthy, T., Nair, G.B. and Kundu, M. (2002) Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae  Antimicrob. Agents Chemother. 46, 2676-2678 

Saha Choudhuri, B., Bhakta, S., Barik, R., Basu, J., Kundu, M. and   Chakrabarti, P. (2002) Overexpression and functional characterization of an ABC transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis. Biochem. J. 367, 279-285 

Mandal, D., Baudin-Creuza, V., Bhattacharyya, A., Pathak, S., Delaunay, J., Kundu, M. and Basu, J. (2003) Caspase 3-mediated proteolysis of the N-terminal cytoplasmic domain of the human erythroid anion exchanger 1 (Band 3) J. Biol. Chem. In press (online October 21, 2003)  

Mechanisms of quinolone resistance in clinical isolates of Shigella dysenteriae. Ahamed, J., Gangopadhyay, J. and Kundu, M.  (1999) Antimicrob. Agents Chemother. 43, 2333-2334. 

Molecular characterization of the SHV-11 b-lactamase of Shigella dysenteriae. Ahamed,  J. and Kundu, M. (1999) Antimicrob. Agents Chemother. 43, 2081-2083. 

Impaired imipenem uptake associated with alterations in outer membrane proteins and lipopolysaccharides in imipenem-resistant Shigella dysenteriae. A.S. Ghosh., Kar, A.K. and Kundu, M. (1998) J. Antimicrob. Chemother. 43, 195-201. 

Alterations in high molecular mass penicillin-binding protein 1 associated with  beta-lactam resistance in Shigella dysenteriae. Ghosh, A.S., Kar, A.K. and Kundu, M. (1998) Biochem. Biophys. Res. Commun. 248, 669-672. 

Involvement of an efflux system in high-level fluoroquinolone resistance of Shigella dysenteriae. Ghosh, A.S., Ahamed, J., Chauhan, K.K. and Kundu, M. (1998) Biochem. Biophys. Res. Commun. 242, 54-56. 

Involvement of a 43 kDa outer membrane protein in beta-lactam resistance of Shigella dysenteriae. Kar, A.K., Ghosh, A.S., Ahamed, J., Chauhan, K., Basu, J., Chakrabarti, P. and Kundu, M. (1997) , Antimicrob. Agents Chemother., 41, 2302-2304. 

Dual multimodular class A penicillin-binding proteins in Mycobacterium leprae. Lepage, S., Dubois, P., Ghosh, T., Joris, B., Mahapatra, S., Kundu, M., Basu, J., Chakrabarti, P., Cole, S.T., Nguyen-Disteche, M. and Ghuysen, J.M. (1997) J. Bacteriol. 179, 4627-4630.

Lipids of Aspergillus. Chakrabarti, P., Kundu, M. and Basu, J. (1996) in Lipids of pathogenic fungi (Prasad, R. and Ghannoum, M.A., eds) CRC Press, pp.140-153 

Identification and overexpression in Escherichia coli of a Mycobacterium leprae gene, pon1, encoding a  high-molecular-mass class A penicillin-binding protein PBP1. Basu, J., Mahapatra, S., Kundu, M., Mukhopadhyay, S., Nguyen-Disteche, M., Dubois, P., Joris, B., van Beeumen J., Cole, S.T., Chakrabarti, P. and Ghuysen, J.M. (1996) J. Bacteriol. 178: 1707-1711.  

Mycotin: a lectin involved in the adherence of Mycobacteria to macrophages. Goswami, S., Sarkar, S., Basu, J., Kundu, M. and Chakrabarti, P. (1994) FEBS Lett. 335: 183-186. 

Characterization of a 38 kDa penicillin-binding protein and its possible involvement in maintaining stationary-phase cells of Shigella dysenteriae. Mahapatra, S., Basu, J., van Beeumen, J. and Kundu, M. (1994) Microbiology 140: 3177-3182. 

Characterization of a lectin from the mollusc Telescopium telescopium. Misra, S., Choudhury, A., Basu, J., Kundu, M., Ghosh, A. and Chakrabarti, P. (1993) Lectins, Biology, Biochemistry, Clinical Biochemistry 8: 199-203. 

Purification and partial characterization of a penicillin-binding protein from Mycobacterium smegmatis. Basu, J., Chattopadhyay, R., Kundu, M. and Chakrabarti, P. (1992) J. Bacteriol. 174: 4829-4832. 

Purification of a phosphatidylinositol/phosphatidylcholine transfer protein from Neurospora crassa. Basu, J., Kundu, M. and Chakrabarti, P. (1992) Biochim. Biophys. Acta 1126: 286-290. 

Erythrocyte membrane proteins in chronic myelogenous leukemia. Basu, J., Kundu, M. and Chakrabarti, P. (1992) Membrane Structure and Functions: State of the Art (Gaber, P.  and Easwaran, K.R.K. eds) Adenine Press, pp. 117-122. 

Fatty acylation of a 55 kDa membrane protein of human erythrocytes. Das, A.K., Kundu, M., Chakrabarti, P. and Basu, J. (1992) Biochim. Biophys. Acta 1108: 128-132.

Defective mycolic acid biosynthesis in a mutant of Mycobacterium smegmatis. Kundu, M., Basu, J. and Chakrabarti, P. (1991) J. Gen. Microbiol. 137: 2197-2200. 

Altered erythrocyte protein kinase C activity and membrane protein phosphorylation in chronic myelogenous leukemia. Kundu, M., Basu, J., Fujimagari, M., Williamson, P., Schlegel, R.A. and Chakrabarti, P. (1991) Biochim. Biophys. Acta 1096: 205-208. 

Chronic myelogenous leukemia: alterations in red cell membrane band 3 and increased IgG binding. Kundu, M., Basu, J. and Chakrabarti, P. (1990) Ind. J. Biochem. Biophys. 27: 456-459. 

Abnormalities of the erythrocyte membrane in chronic myelogemous leukemia. Basu, Kundu, M., Rakshit, M.M. and Chakrabarti, P. (1990) Biotechnology and Applied Biochemistry 12: 501-506. 

Abnormalities in erythrocyte membrane band 3 in chronic myelogenous leukemia. Kundu, M., Basu, J., Rakshit, M.M. and Chakrabarti, P. (1989) Biochim. Biophys. Acta 985: 97-100. 

Changes in membrane lipids and amino acid transport in a nystatin-resistant mutant of Aspergillus niger. Mazumder, C., Basu, J., Kundu, M. and Chakrabarti, P. (1990) Can. J. Microbiol. 36: 435-437. 

Abnormalities in the erythrocyte membrane in acute lymphoid leukemia. Kundu, M., Basu, J., Rakshit, M.M. and Chakrabarti, P. (1989) Biochem. J. 258: 903-906.  

Lectin from Mycobacterium smegmatis. Kundu, M., Basu, J. and Chakrabarti, P. (1989) FEBS Lett. 256: 207-210. 

Liposome-trapped nystatin in growth inhibition of Aspergillus niger. Mazumder, C., Kundu, M., Basu, J. and Chakrabarti, P. (1989) J. Liposome Res. 1: 167-175. 

Abnormal erythrocyte membrane cytoskeleton structure in chronic myelogenous leukemia. Basu, J., Kundu, M., Rakshit, M.M. and Chakrabarti, P. (1988) Biochim. Biophys. Acta 945: 121-126. 

Studies on a lectin from Saccharomyces cerevisiae. Kundu, M., Basu, J. and Chakrabarti, P. (1988) Ind. J. Biochem. Biophys. 25: 204-208. 

Purification and characterization of a non-specific lipid transfer protein from goat liver. Basu, J., Kundu, M., Bhattacharya, U., Mazumder, C. and Chakrabarti, P. (1988) Biochim. Biophys. Acta 945: 134-142. 

Lipid composition and amino acid transport in a nystatin-resistant mutant of Aspergillus niger. Mazumder, C., Kundu, M., Basu, J. and Chakrabarti, P. (1987) Lipids 22: 609-612. 

Chemical modification studies on a lectin from Saccharomyces cerevisiae.(baker’s yeast). Kundu, M., Basu, J., Ghosh, A. and Chakrabarti, P. (1987) Biochem. J. 244: 579-584. 

Isolation and characterization of an extracellular lipase from Neurospora crassa. Kundu, M., Basu, J., Guchhait, M. and Chakrabarti, P. (1987) J. Gen. Microbiol. 133: 149-153. 

Effect of fatty acid supplementation on the thermotropic behavior of membrane lipids and leucine transport in Saccharomyces cerevisiae. Basu, J., Kundu, M. and Chakrabarti, P. (1986) Arch. Biochem. Biophys. 250: 352-359. 

Release of a lectin from a fatty acid auxotroph of Saccharomyces cerevisiae grown in the presence of oleic acid. Basu, J., Kundu, M., Mukherjee, K. and Chakrabarti, P. (1986) Biochem. Biophys. Res. Commun.136: 596-602.